DeAromatase

The major change in hormone concentrations between men and women takes place during puberty. As males begin to develop their secondary sex characteristics, their testosterone levels rise accordingly. This increase in testosterone production in turn decreases the synthesis of SHBG, and ultimately a 3-4:1 testosterone to estrogen ratio is reached. The opposite is true in females. After sexual maturation, estrogen becomes dominant and SHBG production is increased. Since SHBG has a higher affinity for testosterone over estrogen, this increase limits the amount of testosterone available and modifies the hormonal ratio to about 1:2 (testosterone to estrogen).

The reason that DeAromatase works on both men and women is because it is dose dependent. This means that the amount taken is directly tied to the amount of the conversion enzymes and estrogen receptors that are blocked. Through research and testing, it has been established that five (5) servings per day work adequately to help restore the natural hormonal ratios in men. Women need only take three (3) servings per day to help restore their hormonal ratios.

The reason for the differences in dose rates between men and women comes back to their hormonal make-up. Men need more DeAromatase because they need to restore higher testosterone to estrogen ratios. The five servings per day have been shown to effectively reduce the conversion of testosterone to estrogen, which in turn lowers the production of SHBG, which in turn binds less testosterone. The preservation of testosterone coupled with the decrease in binding to SHBG works to restore their homeostatic ratio. Women, need less DeAromatase because they need less overall testosterone for optimal performance. This does not mean that it is less important, in fact, DeAromatase is more important in women because they tend to become excessively estrogenic. Women’s testosterone to estrogen ratio can become skewed much quicker than men due to the double impact of SHBG. As estrogen levels increase, SHBG production increases causing more testosterone to become bound; this effectively lowers the amount of testosterone available. This increase in estrogen, coupled with the subsequent decrease in testosterone, causes their ratios to become severely imbalanced.

One of the most prevalent problems resulting from this extreme estrogen dominance is obesity. Obesity further contributes to estrogen dominance with further production of estrogen by the fat cells, (adipocytes), themselves. Other problems include emotional imbalances and mood swings, lethargy, and impaired immune function resulting in an increased incidence of sickness.