Progesterone suppositories are usually compounded by individual pharmacists and consist of progesterone suspended in a base similar to cocoa butter. Upon insertion, the warmth of the body causes the suppository to melt and release the progesterone. Since suppositories are vaginally administered, the liver does not produce the high number of side effect-causing metabolites that can occur with natural progesterone taken orally. There is some question as to how long the progesterone is effective after insertion. It can be difficult to locate a pharmacy that will compound progesterone suppositories, and the process may cause a lower level of dosing accuracy and quality control.
Patients should considering using a fatty acid base on the prescription to reduce the problems associated with vaginal suppository use. Most progesterone suppositories are stored in individual, sealed, plastic shells. Some women may be sensitive to the suspending substance.
Progesterone suppositories contain progesterone in a wax base. They provide consistent, even absorption. When used vaginally, many women complain of leakage that occurs. When used rectally, some patients report bowel stimulation. Progesterone suppositories were used traditionally and are commonly prescribed in Europe . Progesterone suppositories are usually applied twice a day, 15-17 days before menstruation commences. In the case of a vaginal infection, then it's applied rectally.
We would suggest using a natural progesterone cream like Oasis Serene rather than progesterone suppositories as it is all natural and has no harmful effects. Rather than using progesterone suppositories, Oasis Serene can be used to enhance hormone balance before and after menopause. We recommend Oasis Serene and Oasis Serene Plus, the most chemical-free, all natural (bioidentical) progesterone creams on the market today
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