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(Emulsified Vitamin D-3)
According to the New England Journal of Medicine and the Linus Pauling Institute, one billion people in the world are currently Vitamin D deficient, if 75 nmol/L is used as cutoff value for insufficiency.
The use of a synthetic sunscreen with a sun protection factor (SPF) of 8 can inhibit more than 95% of vitamin D production in the skin. Recent studies have shown that, following the successful "Slip-Slop-Slap" health campaign that encouraged Australians to cover up when exposed to sunlight in order to prevent skin cancer, an increased number of Australians and New Zealanders became vitamin D deficient. Ironically, there are indications that vitamin D deficiency may lead to skin cancer.
Did You Know? Your Body Has 3,000 Receptor Sites for Vitamin D!
Did you know:
While we are all familiar with the importance of vitamin D in calcium absorption and bone metabolism, many doctors and patients are not aware of the recent research on vitamin D and the widening range of therapeutic applications available for cholecalciferol, which can be classified as both a vitamin and a steroid hormone.(1) Additionally, while it was commonly assumed that the upper limit of toxicity was approximately 1,000 IU per day, we now know that the physiologic requirement of vitamin D may be as high as 4,000 IU per day, which is approximately half of the 10,000 IU that can be produced endogenously with full-body sun exposure.(2)
Vitamin D has a well-established role in calcium homeostasis and the maintenance of healthy bone.
Bio-D-Mulsion has excellent absorption due to our unique emulsification process. Recent articles indicate that the prevalence of vitamin D deficiency is much higher than previously recognized (more than 90% in patients with chronic pain, according to a recent study published by the Mayo Clinic), and that vitamin D supplementation is much safer than previously recognized. The recent studies by Al Faraj (2003), Vieth, Chan, and MacFarlane (2001), and Heaney et al (2003) all used daily doses of 4,000 IU per day or more with no evidence of adverse effects.
Vitamin D Physiology
You need to memorize three words, so you can easily read about the vitamin D endocrine system. These three words are cholecalciferol, calcidiol and calcitriol.
Cholecalciferol is formed in the skin when ultraviolet light of the correct wavelength, called UVB, strikes bare skin. Enormous quantities of cholecalciferol are rapidly made in the skin: if the sun is high in the sky (midday and the summer season), if the skin is not covered by clothes or sun block, if you stay in the sun until your skin just begins to turn pink (not red), and if you are not behind glass. Glass blocks virtually all the UVB, preventing vitamin D from being made.
Studies show that if you go out in the summer sun in your bathing suit until your skin just begins to turn pink, you make between 10,000 and 50,000 units of cholecalciferol in your skin. Professor Michael Holick of Boston University School of Medicine, has studied this extensively and believes a reasonable average of all the studies is 20,000 units. That means a few minutes in the summer sun produces 100 times more vitamin D than the government says you need! As discussed in other pages, this is the single most important fact about vitamin D.
The skin does another amazing thing with cholecalciferol. It prevents vitamin D toxicity. Once you make about 20,000 units, the same ultraviolet light that created cholecalciferol, begins to degrade it. The more you make, the more is destroyed. So a steady state is reached that prevents the skin from making too much cholecalciferol. This is why no one has ever been reported to develop vitamin D toxicity from the sun but they can when taking it by mouth.
Cholecalciferol capsules are available in various strengths at health food stores and on the Internet. It is commonly available as 400 unit or 1,000 units capsules. It is manufactured from the fat of lamb's wool by purifying the fat and extracting the cholecalciferol. Fur bearing animals and many birds make cholecalciferol in their fur or feathers as sunlight can not get to their skin. Interestingly, mammals and birds then eat the cholecalciferol by licking their fur (grooming) or rubbing their beaks on their feathers (preening). So, when you take cholecalciferol by mouth, you are doing what a number of other mammals do!
Cholecalciferol is quite potent; which means that it works in small amounts. A 1,000 unit capsule contains 25 micrograms of cholecalciferol. One thousand such capsules would make 25 milligrams. If you look on the label of your bottles you will see that most medications and vitamins are in milligram quantities. 25 milligrams is 1000 times more than 25 micrograms, an important fact to keep in mind. Most of the vitamin D toxicity that has been reported in the medical literature is when manufacturers mistakenly substitute milligrams of cholecalciferol (or even grams) for micrograms, thus making a vitamin D preparation that is 1,000 times (or 1,000,000 times) stronger than it should be. For this and other reasons, in most European countries vitamin D preparations are only available by prescription.
After it is made in the skin or taken by mouth, cholecalciferol is transported to the liver where it is metabolized into calcidiol or 25(OH)D. Calcidiol is now thought by some scientists to have steroid hormone properties. It certainly helps maintain your blood calcium levels. But calcidiol's main importance is that it is the storage form of vitamin D. Calcidiol is what fills your vitamin D gas tank. If your serum calcidiol level is less than 40 ng/ml, your tank is low, and you should fill it up and keep it full unless you have one of those rare medical conditions called vitamin D hypersensitivity (discussed elsewhere).
In order to understand why you should keep your vitamin D tank full, you need to understand the next step in the metabolism of cholecalciferol. After your liver turns cholecalciferol into calcidiol, calcidiol follows one of two roads. The first road takes priority, as your life literally depends on it, but the second road is causing all the excitement. However, if your tank is low, most of your calcidiol takes the first road.
The first road leads to the kidney, where calcidiol is turned into calcitriol. Calcitriol is a potent steroid hormone, in fact, it the most potent steroid hormone in the human body. (A steroid hormone is simply any molecule in the body that is made from cholesterol and that acts to turn your genes on and off. They are always important to health, always need to be handled with care and are often quite potent).
Remember how cholecalciferol is active in microgram quantities, 1/1,000,000 of a gram? Well calcitriol is active in picogram quantities, a picogram is 1/1,000,000,000,000 of a gram!
Calcitriol made by the kidney circulates in the blood to maintain your blood calcium levels. Without enough calcitriol in your blood, your calcium will fall and you will get sick as calcium is vital to the function of the cells in your body. Therefore, the first priority for calcidiol, is to go to the kidney and make enough calcitriol to regulate your serum calcium. This is called the endocrine function of vitamin D as the kidney makes the hormone calcitriol and then secretes into the blood, just like your thyroid gland does with thyroid hormone.
The second vitamin D road leads to your tissues and that where all the action is. All of the amazing health benefits of vitamin D discovered in the last 10 years are from vitamin D going down the second road. If any calcidiol is left over, that is, if your tank is full and your kidneys are getting all the calcidiol they need to maintain serum calcium, then calcidiol is able to take another road, one that leads directly to the cells. This path is only now being fully understood and is causing excitement all around the world, especially concerning cancer. These are the autocrine (inside cell) and paracrine (around the cell) function of vitamin D system.
These functions are crucial to understanding why you should keep your vitamin D tank full. If you only have a small amount of calcidiol in your blood, virtually all of it goes to your kidney, which then makes extra calcitriol to keep your serum calcium levels from falling. Almost no calcidiol gets to your tissues to make tissue calcitriol.
But, when your tank is full, the left over calcidiol goes to the many cells in the body that are able to make their own calcitriol to fight cancer. They do so with gusto. In fact, they appear to make as much calcitriol as they can. The more calcidiol they get, the more calcitriol they make. The step is not rate limited by its product (calcitriol) and is thus uncontrolled. No other steroid hormone system in the body works this way; the manufacture of calcitriol in the tissues is unique. This is the second most important fact about vitamin D.
Other steroids limit their own production by inhibiting the very chemical reactions that make them. For example, a chemical reaction in the body turns cholesterol into progesterone, a female hormone. When enough progesterone is made, progesterone shuts down (inhibits) the chemical reaction so no more progesterone is made. This is called negative feedback. This occurs with all other steroids, somewhere in the metabolic process. If it didn't, the body would not be able to precisely regulate steroid hormone levels.
It does not appear to occur with calcitriol in the tissues! Throughout the entire range of normal calcidiol levels, tissue calcitriol levels continue to increase. The scientific way of saying that is the Michaelis Menton constant remains above one through the full range of the substrate concentration.
This is a crucial piece of information, because it has such profound implications for the normal state of human affairs. Just as modern humans have been living (and dying) with historically low levels of calcidiol in their blood, their tissues have been living (and dying) with historically low levels of calcitriol. And calcitriol is the most potent steroid hormone in the human body. It turns genes on and off at a dizzying rate.
What prevents tissue calcitriol levels from getting too high? Something has to or your tissues would make too much. One thing that helps is called catabolism or breakdown. The more calcitriol that is made, the more is metabolized and excreted in the bile. But that doesn't prevent too much from being made in the first place.
Let's go backwards for a minute. One possible way of limiting calcitriol in the tissues is by limiting the amount of calcidiol in the blood. That is, maybe chemical reaction that turns cholecalciferol into calcidiol in the liver is rate limited, or has a negative feedback loop?
No, it does not. In normal humans, the more cholecalciferol in the blood, the more calcidiol the liver makes. So, in the natural state, what limits the amount of cholecalciferol in the blood? What is the rate limiting step for the production of calcitriol in the tissues?
Your skin! How much you go into the sun. Remember, the body has a fool proof method of limiting cholecalciferol. Only about 20,000 units can be made in the skin every day because the same sunlight that makes it, begins to break it down. After your skin turns dark (tan) even less cholecalciferol is made, maybe 10,000 units. Humans have a natural system in the skin that prevents toxicity. Another way of saying this is that the rate-limiting step for the production of calcitriol in the tissues is your behavior; how often you go into the sun or how much cholecalciferol you take as a supplement. This makes vitamin D unique.
Remember, our ancestors lived naked in the sun for several million years. Then, 50,000 years ago, some of us migrated north and south to places with less sun. Then we put on clothes, started working inside and living in cities where buildings blocked the sun. Then we started traveling in cars instead of walking or riding horses and glass blocked even more of the UVB in the sunlight. Then, only a few years ago, we started actively avoiding the sun and putting on sun block. All this time we have been steadily reducing the tissue levels of the most potent steroid hormone in your body, one with powerful anti-cancer properties.
Remember, vitamin D may be toxic in overdose although one expert recently said, "worrying about vitamin D toxicity is like worrying about drowning when you are dying of thirst. That said, many people think if a little is good then a lot is better. This is definitely not true about vitamin D. Forewarned is forearmed. The only way to know how much might help is to either read the current scientific literature or read our summations on this web site and then decide for yourself.
Vitamin D deficiency and musculoskeletal pain
Vitamin D deficiency causes dull, achy musculoskeletal pain that this incompletely responsive to both pharmacologic and manual treatments. The pain may be widespread or confined to a particular area, most commonly the low back and lumbar spine. The mechanism by which this pain is produced has been clearly elucidated: 1) vitamin D deficiency causes a reduction in calcium absorption, 2) production of parathyroid (PTH) hormone is increased to maintain blood calcium levels, 3) PTH results in increased urinary excretion of phosphorus, which leads to hypophosphatemia, 4) insufficient calcium phosphate results in deposition of unmineralized collagen matrix on the endosteal (inside) and periosteal (outside) of bones, 5) when the collagen matrix hydrates and swells, it causes pressure on the sensory-innervated periosteum resulting in pain.(3) Indeed, several clinical investigations have recently shown that vitamin D deficiency is particularly common among people with musculoskeletal pain.(4, 5)
Non-musculoskeletal manifestations of hypovitaminosis D
Both the peripheral and central nervous systems have multiple sites of action for vitamin D, and it appears likely that vitamin D modulates serotonin and melatonin synthesis and metabolism. Alterations in vitamin D levels appear to explain, at least in part, the adverse psychological effects of sunlight deprivation, such as which occurs in winter.(6) Preliminary evidence suggests that vitamin D deficiency may also be particularly common among patients with inflammatory and autoimmune disorders, and that vitamin D may modulate inflammatory responses.(7, 8, 9)
Bio-D-Mulsion and the importance of micro-emulsification
Independent clinical experience suggests that our micro-emulsion form of vitamin D provides significant improvements in serum levels of 25-OH-vitamin D following supplementation.(10) Each drop of Bio-D-Mulsion supplies a full 400 IU of vitamin D3, micro-emulsified for greater absorption and utilization - particularly important for those with malabsorption conditions. With an increased knowledge of the importance of maintaining adequate Vitamin D levels, many clinicians recommend supplementation and annual screening for 25-OH-Vitamin D levels, especially for patients at risk for deficiency and those who may benefit from supplementation.
Plotnikoff GA, Quigley JM. Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain. Mayo Clin Proc. 2003 Dec;78(12):1463-70
Al Faraj S, Al Mutairi K. Vitamin D deficiency and chronic low back pain in Saudi Arabia. Spine. 2003 Jan 15;28(2):177-9Excerpt from Chapter 16: Vasquez A. Integrative Orthopedics: Concepts, Algorithms, and Therapeutics - The Art of Creating Wellness While Managing Acute and Chronic Musculoskeletal Injuries, 2004.Yamashita H, Noguchi S, Takatsu K, Koike E, Murakami T, Watanabe S, Uchino S, Yamashita H, Kawamoto H. High prevalence of vitamin D deficiency in Japanese female patients with Graves' disease. Endocr J. 2001 Feb;48(1):63-9Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr. 1999 May;69(5):842-56Vieth R, Chan PC, MacFarlane GD. Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level. Am J Clin Nutr. 2001 Feb;73(2):288-94
Heaney RP, Davies KM, Chen TC, Holick MF, Barger-Lux MJ. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr. 2003 Jan;77(1):204-10
*Bucci LR, Pillors M, Medlin R, Henderson R, Stiles JC, Robol HJ, Sparks WS. Enhanced uptake in humans of coenzyme Q10 from an emulsified form. Third International Congress of Biomedical Gerontology; Acapulco, Mexico: June 1989
The Best Articles on Vitamin D
Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety.
Vieth started it all with this masterful paper on the unwarranted fear (bordering on hysteria) of vitamin D toxicity.
Vitamin D in preventive medicine. Are we ignoring the evidence?
Zimmermann reviews the numerous illnesses associated with vitamin D deficiency and the evidence those illnesses are helped by vitamin D.
Vitamin D: A Millenium perspective.
Holick reviews the biology of vitamin D and the extent of the problem of vitamin D deficiency.
Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol.
Heaney and colleagues discover that healthy humans use between 3000-5000 IU of vitamin D a day (if they can get it). This is approximately 10 times more than what the Food and Nutrition Board says is adequate intake.
Calcium Absorption Varies within the Reference Range for Serum 25-Hydroxyvitamin D.
Heaney and colleagues discover that patients with 25(OH)D levels of 86 nmol/L (34 ng/ml) absorbed 65% more calcium than subjects with 25(OH)D levels of 50 nmol/L (20 ng/ml). This study leaves us wondering if the reason Americans need 1500 mg a day of calcium is because most of us are vitamin D deficient.
Product: Bio D-Mulsion (Vitamin D-3)
Size: 1 Fluid Ounce bottle
Serving Size: 1 Drop
|Ingredient||Amount Per Serving||% Daily Value|
|Vitamin D (as cholecalciferol)||
Recommendation: Take with largest meal of the day. 1-5 drops each day as a dietary supplement or as otherwise directed by a healthcare professional.
Bio-D-Mulsion is an oil-in-water emulsion. Vitamin D oil has been dispersed into microscopic particles to aid absorption and assimilation.
Warning: This product is intended to be used under the direction and supervision of a healthcare professional. Use only as recommended unless other directed. Excessive consumption of vitamin D has been shown to cause serious health concerns. Store in a cool, dry area. Keep Out Of Reach Of Children.