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Calcium Orotate

One of the three mineral transporters that are the most active in providing support for bone decalcification. Has a pronounced anti-inflammatory effect on arthritis, arteriosclerosis, retinitis, encephalitis and phlebitis, psoriasis, high blood pressure, multiple sclerosis and colitis. Very effective in re-calcifying the bone tissue following extensive radiation treatment of cancerous bone lesions. Only Calcium Orotate penetrates directly through the cell membrane, delivering calcium to the interior of the cell where it is readily utilized.

Calcium Orotate tablets have been beneficial in:

• Assisting with prevention of osteoporosis.
• Helping to avoid muscle cramps.
• Relieving the pain associated with disc problems.
• Maintaining strong bones & teeth.
• Keeping your heart beating regularly
• Alleviation of insomnia.
• Helping the body metabolize iron
• Reduced Stress
• Increased alertness.

 

Featured Testimonial

"Dear Dr. Lanphier,
Since my research indicates that Calcium Orotate is one of the best absorbed Calciums, I chose it for that reason. Most calcium is of the cheap inorganic type and I asked myself the question: How could Carbonate or chalk be good for you. My second order gives you my answer.

Sincerely,
Charlotte S."

 

What is Calcium Orotate

About Calcium Orotate

Dr. Hans Nieper's theoretical explanations of the mechanisms behind his stunning success in the clinical application of sophisticated mineral transporters rely heavily on the concept of the fixed pore mechanism of active transport. The theory called fixed pore mechanism suggests that a carrier molecule, in this case Orotic Acid (B-13), is attached to the compound being transported. This research has lead to the creation of mineral chelates called orotic acid chelates, or orotates which offers a 20 fold increase in utilizing minerals.

Nieper promoted orotates as treatments for nearly every ailment imaginable and was consequently ignored; most of his medical claims were never rigorously tested. But in certain applications — such as athletic performance — where his ideas have recently received scientific scrutiny, they have been found to work. Nieper may have been on the right track after all.

Calcium Orotate was used by Nieper to treat bone loss and pain due to inflammation or osteoporosis, high blood pressure, angina pectoris, multiple sclerosis, encephalitis, retinitis, hepatitis, arthritis, arteriosclerosis, phlebitis and colitis. In addition, it is very effective against psoriasis, a scaling skin disorder. The long-term clinical tolerance and overall value of calcium orotate is far superior to other therapeutic calcium substances and to the so-called immune depressors.

Orotates are mineral salts of orotic acid — used by plants and animals to make DNA and RNA. Hans Nieper, a physician and dabbler in offbeat theories of gravitation, used orotates clinically prior to 1980. He thought that orotate salts, being neutrally charged, pass easily through cell membranes. In effect, orotate ferries the mineral atoms into cells and tissues, producing higher concentrations.

Overview of Dr. Nieper's Mineral Transporter Formulations With Questions

What Are The Advantages Of Mineral Transporters?

Mineral transporters have a much higher absorption rate (70-90%). Free minerals stay bound up and are for the most part unavailable to the cell membranes for use...they're too unspecific. These are Tissue Specific minerals. Mineral Transporters are absorbed in an Intact State (general free minerals aren't) Mineral Transporters are attracted to and bio-utilized by specific tissues of the body, making therapeutic use more specific and effective. They act as "homing pigeons" for certain tissues. In today's terms, these are called "Targeted" minerals because they're delivered to specific tissues at specific cellular locations...

How Are These Different From Other Mineral Supplements?

They provide selective organ uptake / nutrition They provide an opportunity for sub-cellular nutrition They are analogous to "Special Delivery" v.s. "Bulk" Mail

What Are The Advantages Of Mineral Transporters?

Minerals are transported "in tact" into the cells without the concern of hydrochloric acid to break them down The transport molecule is then incorporated into biochemical processes, releasing the mineral at specific sites in the cell membrane and inside the cell itself at specific targets.

Mineral Bio-utilization

Absorption is only one facet of bioutilization. Suplements that transport ionized minerals into the blood stream are less available at a cell level than mineral transporters, which are able to penetrate the cell membrane and enter the cell. Ionized minerals may or may not enter the cell and be available for use intracellularly.

Biological Utilization Of Minerals

Involves not only absorption, but also transport and delivery to the tissues where they're needed. Mineral transporters solve these issues since they have high absorption and are absorbed in tact. Mineral transporters have the ability to cross the cellular membrane and the cell membrane barrier, delivering the cells in a form the cells recognize and can utilize immediately. Mineral transporters are efficiently taken up by specific tissues orotates are taken up by tissues that embryonically from mesenchyme: bone, cartilage, liver, blood vessels, heart and the blood brain barrier. Aspartates are taken up by muscles, heart, liver, breast and endocrine tissues

Why Use Mineral Transporters When They're More Expensive?

Because pharmacological doses of nutrients can create imbalances in other nutrients (pharmacological doses are those that are higher than physiological norms). Instead, mineral transporters deliver minerals in physiological doses to tissues and cells, reducin the potentil of creating tissue damage and antagonism with other nutrients. Because of the poor utilization of other forms of minerals and the higher dosing required, these transporter mineral forms from Neiper are actually LESS expensive overall than other forms or delivery systems.

Why Are Neiper Mineral Transporters Superior To Other Mineral Transporters?

Dr.Neiper found that mineral transporters work better, when each granule is enterically coated by a micro-vortex process, which ensures intact passage of the compound through the acidic environment of the stomach. Other products who don't utilize this patented process end up providing "free" minerals and amino acids, which aren't targeted (tissue specific). Micro-vortex coating of mineral transporters is when individual granules are enterically coated with a soluable compound which resists the stomach acid and yet is readily dissolved in the alkaline environment of the small intestine. Micro-vortex enteric coating delivers the mineral transporter into the small intestine in tact where it is moved into the blood stream in tact, where the transporters enter the cells and the minerals are released at specific cell sites.

Mineral Transporters
Excerpt from: New Dynamics of Preventive Medicine, 1974
By: Hans Nieper, M.D.

I think a few of you have already heard of the concepts of active mineral transports in directed therapy. I will give you a tour of horizons of what active mineral transport is and what it can do and how it is to be explained.

Late in the l950s it was discovered that cells of the female breasts becoming malignant are going to lose magnesium so we thought why not conceive of an extra-active transport principle to take magnesium into these cells with the help of phenylalanine and paraminobenzoic acid. At the same time, Hans Selye's book on the prevention of myocardial necrosis with the help of potassium and magnesium chloride was published and so we developed, in fulfilling the requirements of more active transport of potassium and magnesium into the cell, the potassium-magnesium aspartate in 1957-1958. This became quite successful world-wide as a medicament for the protection of myocardial necrosis, enhancement of liver functions and the detoxification of digitalis. Since this has been so successful, we followed this concept of active mineral transport and we changed as well the mineral which had to be transported as also the molecules which are suitable to transport the mineral into a cell by means of artificially created active transport. So the most important transporters we have today are aspartic acid, 2-aminoethylphosphoric acid and orotic acid.

2-aminoethylphosphoric acid (AEP) is a substance which plays a role as a component in the cell membrane and at the same time has the property to form a complex with minerals. You may replace the calcium by magnesium, potassium, iron or whatever. This substance goes into the outer layer of cell membrane is decomposed there, incorporated into the cell membrane and releases the ion upon metabolization.

The second substance, the aspartates, especially the L-aspartate. goes to the inner layer of the outer cell membrane and there, upon metabolization releases the mineral to become the ion.

The third substance which interests us enormously is orotic acid which forms a high complex salt with any mineral and which has no metabolic affinity to the outer cell membrane but penetrates the outer cell membrane even in the form of a complex salt and is only metabolized at the site of the membranes of the mitochondria and of the structures found in the cell plasma. Only here the mineral will be released to the form of an ion.

So we have three different kinds of transporters: The AEPs (outer layer of the outer cell membrane), the aspartates (inner layer of the outer cell membrane) and the orotates (cell plasma organelles).

All three substances are officially on the market in Germany and they play an important role in cardiology and hepatology for the aspartates. In the prevention and the treatment of multiple sclerosis, for the AEP, calcium potassium magnesium AEP is officially declared in Germany as the only active substance in the treatment of multiple sclerosis. The myelin is a multilayer of cell membrane and AEP goes there, fits as a membrane component in the damaged membrane in the case of multiple sclerosis, releases the calcium at the same time which shields against aggression by antibodies.

The orotates are officially on the market for the treatment of numerous diseases, especially decalcification and immune aggression toward the cell.

Keep this in mind: different transporters go to different structures inside the cell. We will direct ourselves to calcium orotate.

Calcium orotate really performs clinical effects in various diseases connected with decalcification and injury of bones which can rapidly be improved by means of the application of calcium orotate by using this new concept of active mineral transport since we know, especially in studies run in Zurich, that all formation of bone, more or less, is controlled by cell membrane and that the microgranules of apatit have to be formed inside the osteoblast and then released through the cell membrane again.

A patient's leg was sliced off with all the attendant injuries of vessels. It was almost impossible to heal him by conventional means. He received calcium orotate for two years and he is now able to walk around. He telephoned me recently and said he is in excellent shape. This is one of the accidents and injuries which really needs calcium orotate to achieve the best results which are obtained today in my opinion.

Bone fractures have been treated unsuccessfully for several months and years without formation of callus or healing. The bone fractures were due, in one case, to an immune arteriolitis. Upon application of calcium orotate, within six weeks the patient returned to normal functions and had no more complaints.

Especially in Europe more than in this country, decalcification has to do with the higher carbohydrate intake. In Germany we have a tremendous amount of, more or less, severe damages in the dorsal spine. A 28-year-old patient suffered with juvenile decalcification and severe osteochondrosis There was no help for this patient, not by hormones or conventional calcium. However, upon treatment with calcium orotate he became normal in every respect within a few weeks and is still without any complaints.

Now here I have to stress a little bit the aspects of the transport by the orotates. The orotic molecule is mostly taken up by mesenchymal tissue and by bradytrophic tissue, especially by cartilage tissue and also by the vessel walls, by the blood-brain barrier and by the matrix of the bone. It is much less taken up by epithelial tissue such as liver epithelium glands, and so on, or mucosa, in contrast to the AEP, for instance. We learned, during the months and years that the improvement which we observed in dorsal spine complaints upon the application of calcium orotate, obviously had not so much to do with an improvement of the recalcification, or the improvement of the density of the bone tissue, but with the protection given to the tissue and cartilage surface by means of active calcium transport into cartilage tissue with the help of orotic carrying molecule.

The orotic acid plays a very important role to so-called pentose pathway metabolism which accounts for the metabolism in cartilage tissue and especially for all organs which account for aging. There, the ribose coupling needs orotic add and therefore obviously the orotic carrying molecule has a high affinity to this kind of tissue, like cartilage which, so far, we were unable to influence and which experienced even more damage under the influence of cortisone. Therefore, calcium orotate seems to me to be one of the most important substances to prevent cortisone side effects in, eg, rheumatoid arthritis. This is very important.

I could speak much longer on this problem. However I want you to have a certain impression. During the following years in which you will stay healthy with the help of orotates, you will be able to learn more and more about this. A I 4-year-old girl, unsuccessfully treated so far with every imaginable medication, was entirely relieved with calcium orotate, because the calcium orotate goes into this connective tissue which develops in the frame of this disease, as well as in Pertlies disease, as in Schlatter disease and in Recklinghausen's disease.

By the way, I have quite a few patients who after the intake of contraceptive pills developed cartilage damage. The application of calcium orotate allows the continuation of the intake of these contraceptives.

A patient with a severe osteochondrosis was almost entirely immobilized. After six weeks of treatment, there were no more complaints. Astonishingly enough, there is no parallel between the lack of increasing density of bone tissue and improvement, which again points into the direction that the origin of pain in spinal syndrome has to do with cartilage behavior and less so with osteoporosis as such. A 64-year-old lady with severe decalcification and in severe pain had a disc slipped off a vertebra. She was treated unsuccessfully for years and is now without any complaints for two years. Although without any radiological improvements she is fine. In the case of severe osteochondrosis in an 18-year-old patient, she was almost immobilized two years ago. She has now absolutely no complaints and is mobile, despite the fact that there is no change in roentgenologic finding.

What we see in Europe in dorsal spine deformation is alarming. I do not know if you have a parallel in the United Slates. From the literature, I learned that decalcification problems in Europe play a much more important role than in this country because in the United States the protein intake is, on the average, higher.

We learned recently that Bechterew disease is an autoimmune disease related to rheumatoid form and astonishingly enough as well as the intravenous application of calcium AEP as the application of calcium orotate gives very important relief in these patients. We have the feeling that the application of the orotates blocks the immune processes which lead to an abnormal arid ectopic calcification in these patients. They become partly remobilized and we have patients who gained about 20 degrees in upright position. Especially, there is no more pain. I have quite a series of Bechterew disease patients and they were always very much helped by this kind of treatment, where previously all other imaginable treatment failed. One patient had this disease for about 13 years and after 11 years of ailing we started the treatment with calcium AEP intravenously and calcium orotate there were no more complaints, she resumed normal housekeeping and gained about 20 degrees of an upright position. Another patient was an 82-year-old lady with excellent activity. Only in upright position she had unbeatable pain and when lying down had no pain at all. This is a typical symptom for chondrosis. Upon impact on the cartilage the pain developed. After the treatment with calcium orotate (3 gm/day) she had no more pain at all. She is going around in a Fiat sports car at 82 years of age.

Arthrosis of the hip shows good results with the treatment of calcium orotate. Of course, you cannot replace damage and lesion. However, we have the feeling that once the first signs of osteochondrosis develop, the long-time treatment with calcium orotate helps a lot and at least stretches out the time until eventually the arthrosis will have developed to become a surgical problem. The protection of the cartilage layer really is the mechanism which accounts for the prevention of osteochrondosis and of arthrosis.

We have quite a series of patients with severe osteoporosis with arthrosis on both sides who underwent operations and were previously, for about six months, treated with calcium AEP and calcium orotate. Surgeons reported a very important hardening of the spongiosal structure of the bone and all over it seems that the results, especially upon the implantation of the metal, seem to be much better after such a pretreatment than without it.

In Houston, Texas, four years ago at the Cancer Congress, I presented a series of patients who had developed metastatic disease, mostly breast cancers with bone metastases. We started about five years ago. This was the first clinical step with calcium orotate to try to recalcify these metastases. We found that calcium orotate has no side effects at all. It is more successful than sodium fluoride in the calcification of bone metastases and we had excellent and reliable success in about 40% of all metastatic disease in the bone system. One patient had very severe lesions in the left hip. After treatment with calcium orotate for about eight weeks this patient was free from any complaints, the lesions were mostly recalcified. This patient, too, went around in a Flat sports car without having any complaints.

Another patient came with 200 parts per million of serum calcium pretreatment with important doses of conventional calcium which resulted in hypercalcemia, a dangerous situation concerning the heart rate and heart metabolism, with thousands of metastases and practically in a terminal situation. After about four months of treatment with calcium orotate there was almost entire recalcification. The results speak for themselves: no more complaints.

This is calcium orotate, it's effect on recalcification of bone metastases on cartilage tissue and also on osteoporosis. Without any doubt, clinically, it is obvious that there is no calcium compound known which affects cartilage tissue and which prevents damage on pentose pathway tissue such as cartilage. I feel this is quite a bit of progress in preserving our health and especially in preventing aging of tissue.

Other Orotates (available from OAW by request)

Magnesium orotate
Used by competitive athletes to increase endurance. It is also used to treat symptoms of magnesium deficiency, including diabetes, hypertension, dementia, and osteoporosis, and to treat migraines, asthma, chronic lung disease, heart attacks, arrhythmia's, blood vessel stiffness, atherosclerosis, and high blood pressure.

Potassium orotate
Used to treat symptoms of magnesium deficiency: diabetes, insulin resistance, high blood pressure, rheumatoid arthritis, and heart disease. Nieper combined potassium and magnesium orotates to treat cardiovascular diseases. Other applications include wound healing, immune enhancement, depression and anxiety.

Zinc orotate
Used to treat symptoms of zinc deficiency: osteoporosis, hypogonadism, low testosterone levels, cardiovascular disease, diabetes, atrophy of the thymus, low white blood cell counts, and lowered immunity. In Nieper’s opinion, zinc orotate works better than other zinc salts.

 

Supplement Facts and Usage

Net Contents:  100 tablets

Usage
As an addition to the daily diet. Take two to three tablets with evening meal or as directed by your healthcare provider. If you are pregnant or nursing, consult your healthcare provider before using this or any dietary supplement.

Ingredients
Per 3 Tablets:

Calcium (as calcium orotate) 1.5g

Magnesium (as magnesium L-aspartate and as magnesium hydrogen phosphate trihydrate) 337mg

Finally The Truth About Calcium Supplements

By Loretta Lanphier, ND, CN, HHP

Undoubtedly calcium has become a hot topic of controversy. We are bombarded with advertising telling us exactly what will give our body more calcium. Between the “Got Milk?” slogans on one end and the Coral Calcium “cure-all” TV spots on the opposite end it is time that the truth be exposed. Let’s look at why we need calcium and then some signs of calcium deficiency.

How the Body Uses Calcium:

• Strong bones, teeth and gums Maintaining a regular heartbeat The lowering of cholesterol Helps prevent cardiovascular disease Needed for muscular growth and contraction Prevents muscle cramps Essential in blood clotting Helps prevent cancer May lower blood pressure May prevent bone loss associated with osteoporosis Helps to activate enzymes which breaks down fats Maintains proper cell membrane permeability Helps keep skin healthy Protects against preeclampsia during pregnancy < Can help reduce high blood pressure in pregnancy
• Protects the bones and teeth from lead by inhibiting absorption of this metal

Calcium DeficiencySymptoms:

• Aching joints Brittle nails Eczema Elevated blood cholesterol Heart palpitations High blood pressure Muscle Cramps Insomnia Nervousness Numbness in arms or legs Rheumatoid arthritis Tooth decay Depression Hyperactivity Hives
• Psoriasis

“Got Milk?”…Are You Really Getting Calcium?

No way! The damage that this one slogan is doing to the health of Americans, especially children, is tremendous. Consider the following written by Robert Cohen (www.notmilk.com):A publication in the February, 2003 issue of the American Journal of Clinical Nutrition (Vol. 77, No. 2, 504-511) clearly demonstrates that eighteen years of milk consumption did not prevent hip fractures for post-menopausal women.

How many subjects participated in the study?

A mere 72,337. As part of Walter Willett's Harvard Nurses Study, investigator Diane Feskanich performed statistical tests of significance for 18 years of data including dietary intake of calcium (dairy and supplements) to determine her findings.The conclusion reached from this observational analyses, is that dietary calcium plays little or no role in preventing bone loss. Drinking milk does not prevent osteoporosis. A total of 603 hip fractures were analyzed. Scientists determined that milk consumption was in no way associated with hip fracture risk. The same conclusion was reached for total calcium consumption.The Harvard Nurses study previously determined that there is no positive association between teenaged milk consumption and the risk of adult fractures. (American Journal of Public Health 1997;87). As a matter of fact, just the opposite was found to be true. Women consuming greater amounts of calcium from dairy foods suffered significantly increased risks of hip fractures.In light of these findings, the dairy industry milk mustache campaign has been proven to be one enormous deception. Bones break because women eating the wrong foods create an acid condition in their own bloodstreams, which must be neutralized by available calcium. The body achieves balance by taking calcium out of its own bones. Ergo, people eating the greatest amount of total animal protein are the ones experiencing accelerated rates of bone loss. The same Journal of Clinical Nutrition, (1995; 61, 4) confirmed this truth:"Dietary protein increases production of acid in the blood which can be neutralized by calcium mobilized from the skeleton."Eighteen years earlier, as the Harvard Nurses study was just beginning, the American Journal of Clinical Nutrition (1979;32,4) reported:"Even when eating 1,400 mg of calcium daily, one can lose up to 4% of his or her bone mass each year while consuming a high-protein diet."Why do you imagine that today's most recent study will not be publicized on tonight's 6 PM news, or headlined in your local newspaper? Because it lacks one critical ingredient. Cash. For a story to be released, it must be accompanied by paid dairy industry advertising. In this deceptively dangerous manner, most of us get our biased health information.

Milk? It does not do the body good. Coral Calcium

How these people have been in business so long just amazes me! I used to get spammed at least ten times per day with advertisements suggesting that Coral Calcium cures just about everything!! I have often wondered just where the FDA police was during all of this hype.Coral calcium is calcium carbonate and is no better than the calcium that is available in most drug stores or vitamin stores. What is calcium carbonate? Chalk! Put a piece in a glass of water and see how long it takes to dissolve…believe me, you will be there for longer than you care to know. Yes, you may get some benefit from it but it is not the most absorbable form of calcium and therefore not the most beneficial.

Ridiculous Claims:
It’s from the ocean: Not “everything” in the ocean is wonderful. Ever read about how polluted our oceans are? Enough said. The people in Okinawa live longer and look younger: When doing research on this you will find that their longevity is more than likely contributed to their diet and stress-free life. There is no supplement that will ever take the place of good nutritional balancing. Disease Cure-All: This is the one that makes me cringe. There has not been one study to back up any cure from taking calcium (any kind) alone. Yes, the body needs calcium to function properly, but calcium, by itself, will not cure anything! I do believe in disease elimination using natural methods but there is no magic bullet and no magic supplement. If a company is selling a product claiming a “cure-all” this should raise huge red flags.

Calcium Orotate—The Best From of Calcium Available

According to studies conducted by Dr. Hans Nieper (Germany) only Calcium Orotate penetrates directly through the cell membrane, delivering calcium to the interior of the cell where it is readily utilized.Orotates are mineral salts of orotic acid — used by plants and animals to make DNA and RNA. Hans Nieper, a physician and dabbler in offbeat theories of gravitation, used orotates clinically prior to 1980. He thought that orotate salts, being neutrally charged, pass easily through cell membranes. In effect, orotate ferries the mineral atoms into cells and tissues, producing higher concentrations.Nieper promoted orotates as treatments for nearly every ailment imaginable and was consequently ignored; most of his medical claims were never rigorously tested. But in certain applications — such as athletic performance — where his ideas have recently received scientific scrutiny, they have been found to work. Nieper may have been on the right track after all.Dr. Nieper's theoretical explanations of the mechanisms behind his stunning success in the clinical application of sophisticated mineral transporters rely heavily on the concept of the fixed pore mechanism of active transport. The theory called fixed pore mechanism suggests that a carrier molecule, in this case Orotic Acid (B-13), is attached to the compound being transported. This research has lead to the creation of mineral chelates called orotic acid chelates, or orotates which offers a 20 fold increase in utilizing minerals.Calcium orotate was used by Nieper to treat bone loss and pain due to inflammation or osteoporosis, high blood pressure, angina pectoris, multiple sclerosis, encephalitis, retinitis, hepatitis, arthritis, arteriosclerosis, phlebitis and colitis. In addition, it is very effective against psoriasis, a scaling skin disorder. The long-term clinical tolerance and overall value of calcium orotate is far superior to other therapeutic calcium substances and to the so-called immune depressors.Calcium Orotate is one of the three mineral transporters that is the most active in providing treatment for bone decalcification. Has a pronounced anti-inflammatory effect on arthritis, arteriosclerosis, retinitis, encephalitis and phlebitis, psoriasis, high blood pressure, multiple sclerosis and colitis. It can be very effective in re-calcifying the bone tissue following extensive radiation treatment of cancerous bone lesions.

Calcium Orotate tablets have been beneficial in:

1. Assisting with prevention of osteoporosis. Helping to avoid muscle cramps. Relieving the pain associated with disc problems. Maintaining strong bones & teeth. Keeping your heart beating regularly Alleviation of insomnia Helping the body metabolize iron Reduced Stress
2. Increased alertness

We use Calcium Orotate along with the other orotates (magnesium, potassium, zinc and lithium) at Oasis Advanced Wellness in a whole body, synergistic approach to eliminating disease. The results that we see using calcium orotate conclude that it is absorbed, transported and utilizied in the body better than any other form of calcium. It is time that the public knows the truth about calcium, its many benefits, why it is necessary and the best form available. Remember that he first step in getting healthy is always education and I believe that it is your right to know the truth about every hopeful treatment and prevention option available to you.

About The Author

Loretta Lanphier, ND, CCN, HHP is a Doctor of Naturopath, Clinical Nutritionist and Holistic Health Practitioner in the Houston, TX area and CEO/President of Oasis Advanced Wellness.  A teacher and educator, she counsels Oasis Advanced Wellness clients on the aspects of getting the body healthy and keeping the body healthy. As a cancer survivor, she is able to relate extensively, both as a patient and a practitioner, to clients suffering from disease. She is also involved in researching new alternative disease treatments and products. Dr. Lanphier is Editor and contributor to the worldwide newsletter Advanced Health & Wellness.